N,N-Dimethylformamide-stabilized palladium nanoclusters as catalyst for Migita–Kosugi–Stille cross-coupling reactions

•Highly active Pd nanoclusters catalyst in Migita–Kosugi–Stille coupling reaction.•A practical cross-coupling catalyst system with high TONs (3.5 × 104).•A practical cross-coupling catalyst system that do not need the use of an inert gas.

N,N-Dimethylformamide-stabilized palladium nanoclusters showed high catalytic activity for Migita–Kosugi–Stille cross-coupling reactions. The present cross-coupling reaction proceeded efficiently using very small Pd catalyst loadings under ligandless, and even an open air, conditions. The reactions proceeded smoothly in good yields and with high turnover numbers of up to 3.5 × 104.

Graphical abstractN,N-Dimethylformamide-stabilized palladium nanoclusters showed high catalytic activity for Migita–Kosugi–Stille cross-coupling reactions. The present cross-coupling reaction proceeded efficiently using very small Pd catalyst loadings under ligandless, and even an open air, conditions. The reactions proceeded smoothly in good yields and with high turnover numbers of up to 3.5 × 104.Figure optionsDownload full-size imageDownload as PowerPoint slide