Palladium-catalyzed site-selective CH alkenylation of imidazo[2,1-b]thiazoles

•Pd-catalyzed alkenylation of imidazo[2,1-b]thiazoles with alkenes.•Dehydrogenative Heck coupling reaction.•Site-selective CH bond activation.•Efficient access to synthesis of polysubstituted imidazo[2,1-b]thiazoles.

Dehydrogenative alkenylation of imidazo[2,1-b]thiazoles via palladium(II)-catalyzed site-selective CH bond activation has been developed in moderate to good yields under aerobic conditions. This methodology provides a very efficient, direct, and atomeconomical strategies to construct an alkenyl-imidazo[2,1-b]thiazole moiety.

Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide