| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1321856 | Journal of Organometallic Chemistry | 2016 | 7 Pages |
•Pauson-Khand reaction in gas phase has been performed.•The reactivity of alkenes in the gas phase appears to mimic that observed in solution.•Intermediates of Pauson-Khand reaction trapped in gas phase.
The intermolecular Pauson-Khand reaction has been reproduced in the gas phase by using electrospray ionization coupled to modified tandem mass spectrometry. It has been found, as in solution, that the use of a strained alkene is preferred because of its relatively high reactivity. To observe the final cyclopentenone product, the cobaltacycle produced after a first ion-molecule reaction must necessarily collide with CO. Furthermore, when competition between an inter versus an intra-molecular reaction is possible, the intermolecular reaction is favored.
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