| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1321973 | Journal of Organometallic Chemistry | 2013 | 7 Pages |
A series of five monomeric and polymeric complexes: [Bu3Sn(C5H4O2S)] (1), [Me3Sn(C5H4O2S)] (2), [Cy3Sn(C5H4O2S)] (3), [Bu2Sn(C5H4O2S)2] (4), [Oct2Sn(C5H4O2S)2] (5) of thiophene-2-carboxylic acid have been synthesized by the reaction of ligand acid with di- organotin compounds for the complexes 4, 5 and its sodium salt with tri-organotin compounds for the complexes 1, 2 and 3 respectively, in suitable stoichiometries. All complexes have been structurally characterized by vibrational and magnetic resonance (1H, 13C NMR) spectroscopies. The structures of complexes (2), (3) and (4) have also been elucidated by X-ray crystallography. Relative potential has been assessed for their anti-bacterial, DNA protection and inhibitory assay against acetyl cholinesterase and butyryl cholinesterase.
Graphical abstractFive organotin(IV) derivatives of thiophene-2-carboxylic acid [Bu3Sn(C5H4O2S)] (1), [Me3Sn(C5H4O2S)] (2), [Cy3Sn(C5H4O2S)] (3), [Bu2Sn(C5H4O2S)2] (4), [Oct2Sn(C5H4O2S)2] (5) have been synthesized. The structures of complexes (2), (3) and (4) have also been elucidated by X-ray crystallography. The anti-bacterial, DNA protection and inhibitory assay against acetyl cholinesterase and butyryl cholinesterase have been studied also.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Preparation of five tin(IV) compounds of thiophene-2-carboxylic acid. ► Spectroscopic investigation and X-ray crystallography of complexes. ► Significant antibacterial activity of all complexes. ► Good scavenging activities have been shown by the complexes.
