Article ID Journal Published Year Pages File Type
1322064 Journal of Organometallic Chemistry 2012 8 Pages PDF
Abstract

The synthesis of series of 1,2,1′ substituted bis(diphenylphosphino)- ruthenocenyl (1–4) and ferrocenyl cis-platinum(II) (5–7) and gold(I) (8–12) complexes are described. Crystal structures of 2 and 4, as well as 5, 6 and 10 confirm the molecular geometry of these ligands and their metal complexes. Preliminary investigation of four gold complexes as potential anticancer, antiHIV and antimalaria showed at least one gold compound that has excellent activity towards one of these diseases. The three gold(I) complexes, {1- [1-(dimethylamino)ethyl]-1 ,2-bis(diphenylphosphino)ruthenocene-κ2P,P′}bis[chlorogold(I)] (8) (IC50 = 1.40 μM), {1-[1-(acetoxyethyl)-1′,2-bis(diphenylphosphino)ferrocene-κ2P,P′]bis[chlorogold(I)] (9) (IC50 = 0.51 μM), {1-[1-(3-carboxypropanamido)ethyl]-1′,2-bis(diphenylphosphino)-ruthenoceneκ2P,P′}bis[chlorogold(I)] (12) (IC50 = 1.784 μM), have the best activities against cancer, HIV and malaria respectively.

Graphical abstractPlatinum(II) and gold(I) (diphenylphosphino) ferrocene and ruthenocene complexes have been prepared. These gold(I) complexes show remarkable activity towards HeLa cells, type 1 HIV and Plasmodium falciparum.Figure optionsDownload full-size imageDownload as PowerPoint slide

Related Topics
Physical Sciences and Engineering Chemistry Inorganic Chemistry
Authors
, , , , , , , , , , , , ,