| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1322620 | Journal of Organometallic Chemistry | 2010 | 4 Pages |
Abstract
An efficient, convenient, and reliable multi-step synthesis of rac-2′-(trimethylsilyl)isovaline (rac-3) that uses inexpensive reagents in all steps has been developed, starting from diethyl malonate (overall yield 28%). Compound rac-3 is the first α-ethylated α,α-dialkylated silicon-containing α-amino acid.
Graphical abstractAn efficient, convenient, and reliable multi-step synthesis of rac-2′-(trimethylsilyl)isovaline (rac-3) that uses inexpensive reagents in all steps has been developed, starting from diethyl malonate (overall yield 28%). Compound rac-3 is the first α-ethylated α,α-dialkylated silicon-containing α-amino acid.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Steffen Falgner, Ginka Buchner, Reinhold Tacke,