| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1322690 | Journal of Organometallic Chemistry | 2013 | 6 Pages |
•Heterobimetallic ferrocenylthiosemicarbazone complexes have been prepared.•Various phosphorus ligands occupy the fourth coordination site.•The antiplasmodial activity of the ferrocenylthiosemicarbazone complexes was evaluated.•The complexes displayed inhibitory effects in the low micromolar range.
Heterobimetallic ferrocenylthiosemicarbazone palladium(II) complexes (3–5) were prepared through the cleavage of a chlorido-bridged palladium ferrocenylthiosemicarbazone intermediate (2) using various P-donor ligands. These compounds were screened for antiplasmodial activity against chloroquine-sensitive (NF54) and chloroquine-resistant (Dd2) Plasmodium falciparum strains, exhibiting biological activity in the low micromolar range. The compounds generally display well-resolved electrochemically reversible one-electron transfer processes for the ferrocenyl group. The half-wave potential for the Fe(II)/Fe(III) couple is electronically influenced by the type of P-donor group through the palladium(II) centre.
Graphical abstractHeterobimetallic ferrocenylthiosemicarbazone palladium(II) complexes were synthesized through cleavage of the chlorido-bridged ferrocenlythiosemicarbazone tetranuclear palladium precursor. The ferrocenylthiosemicarbazone palladium(II) complexes were evaluated for their antiplasmodial activity and displayed moderate inhibitory effects in the low micromolar range against chloroquine-sensitive and chloroquine-resistant Plasmodium falciparum strains.Figure optionsDownload full-size imageDownload as PowerPoint slide
