Synthesis, crystal structure and in vitro antitumor activity of carboxylate bridged dinuclear organotin(IV) complexes

Two novel dinuclear organotin(IV) complexes [n-Bu2Sn(imda)(H2O)]2·Bipy (1) and [n-Bu2Sn(imda)(H2O)]2·Phen (2) [H2imda = iminodiacetic acid, Bipy = 2,2′-bipyridine and Phen = 1,10-phenanthroline] were synthesised and characterized employing IR, 1H, 13C, 119Sn NMR, and 119Sn Mössbauer spectroscopic and elemental analyses. Single crystal X-ray crystallography of 1 has confirmed that it is a binuclear Sn(IV) species formed via carboxylate bridges where each metal adopted a seven coordinate distorted pentagonal bipyramidal geometry. The iminodiacetate dianion (imda2−) acts as a potential tridentate [N,O,O] carboxylate bridging ligand. The packing revealed that the additional α-diimine (Bipy or Phen) does not coordinate to metal ion. However, its presence in the crystal lattice as spacer helps for the formation of a supramolecular framework by bringing the two binuclear species close enough through extensive H-bonding. The in vitro cytotoxicity of compounds 1 and 2 indicate better results than cisplatin against three tumor cell lines investigated.

Graphical abstractTwo novel dinuclear organotin(IV) complexes with stoichiometry [n-Bu2Sn(imda)(H2O)]2·(L–L) [(L–L) = 2,2′-bipyridine or 1,10-phenanthroline] were synthesised. A distorted pentagonal bipyramidal (pbp) coordination geometry around each {Sn} metal was ascertained from spectral studies including 119Sn Mössbauer and X-ray crystallography. The compounds were also evaluated for their antitumor activities.Figure optionsDownload full-size imageDownload as PowerPoint slide