Palladium complexes containing multidentate phenoxy–pyridyl–amidate ligands: Highly efficient catalyst for Heck coupling of deactivated aryl halides

N,N′,N″,O-Tetrafunctional Pd(II) complexes prepared from the easily available amino acids are shown to be highly efficient catalysts for the Heck reaction of deactivated aryl bromides and iodides with high turnover numbers up to ca.104 and moderate activity for the activation of aryl chlorides under phosphine-free conditions.

Graphical abstractN,N′,N″,O-Tetrafunctional Pd(II) complexes prepared from the easily available amino acids are shown to be highly efficient catalysts for the Heck reaction of deactivated aryl bromides and iodides with high turnover numbers up to ca.104 and moderate activity for the activation of aryl chlorides under phosphine-free conditions.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► N,N′,N″,O-Tetrafunctional Pd(II) complexes prepared from amino acids. ► Highly efficient catalysts for Heck reaction of deactivated aryl bromides and iodides. ► High turnover numbers up to ca.104.