| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1323088 | Journal of Organometallic Chemistry | 2008 | 5 Pages |
The rhodium-catalyzed direct ortho-arylation reactions of phenylazoles using arylboron reagents such as tetraarylborates were examined. Ethyl chloroacetate and potassium fluoride were found to effectively act as a hydrogen acceptor and a promoter, respectively, to afford selective formation of the corresponding mono- or diarylated products with good yields. In addition, azobenzene as well as 2-phenylpyridine also underwent the direct arylation under similar conditions.
Graphical abstractDirect ortho-arylation of phenylazoles with arylboron reagents under rhodium catalysis proceeds efficiently to afford the corresponding mono- or diarylated products. Ethyl chloroacetate and potassium fluoride effectively act as a hydrogen acceptor and a promoter, respectively. Azobenzene as well as 2-phenylpyridine also undergo the direct arylation under similar conditions.Figure optionsDownload full-size imageDownload as PowerPoint slide
