Organic/inorganic salting-in/salting-out agents as promoters of Pd-catalysed ligand free synthesis of biaryls in water

•All the reactions are carried out in water medium at room temperature.•It is a ligand free approach.•Small quantities of ionic additive are required for enhancing the reaction rate.•Good to excellent yields were obtained within a very short reaction time.•Overall, the methodology is quick, versatile and highly efficient.

Biaryls were synthesized using Pd-catalyzed Suzuki–Miyaura cross coupling reactions of aryl halides with aryl boronic acids in water in the presence of organic/inorganic additives as promoters. The coupling reactions, carried out in absence of ligand, proceed in good to excellent yields with easy product isolation and in relatively shorter reaction time.

Graphical abstractSuzuki-Miyaura cross coupling reactions, carried out in absence of ligand, proceed in good to excellent yields with easy product isolation and in relatively shorter reaction time in presence of salting-in and salting-out additives as promoters.Figure optionsDownload full-size imageDownload as PowerPoint slide