| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1323363 | Journal of Organometallic Chemistry | 2012 | 4 Pages |
Reactive iron carbonyl species generated in situ using the Fe(CO)5/t-BuOK/CH3COOH/CH2Cl2 reagent system reacts with alkynes to give the corresponding α,β-unsaturated carboxylic acids after CuCl2·2H2O oxidation with some regio and stereoselectivity.
Graphical abstractReactive iron carbonyl species generated in situ using the Fe(CO)5/t-BuOK/CH3COOH/CH2Cl2 reagent system reacts with alkynes to give the corresponding α,β-unsaturated carboxylic acids after CuCl2·2H2O oxidation with some regio and stereoselectivity.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Hydrocarboxylation of alkynes by using Fe(CO)5/t-BuOK/AcOH/CH2Cl2 reagent system. ► The Fe2(CO)9/t-BuOK/AcOH/CH2Cl2 reagent system is also useful for this conversion. ► Symmetrical alkynes undergo stereoselective hydrocarboxylation. ► Unsymmetrical alkynes undergo regio and stereoselective hydrocarboxylation.
