Synthesis of phenazines by Cu-catalyzed homocoupling of 2-halogen anilines in water

Phenazines are synthesized by Cu-catalyzed homocoupling of 2-iodoanilines or 2-bromoanilines in water in moderate to excellent yields up to 85%.

Graphical abstractA simple, efficient, economical and environmentally friendly protocol for the synthesis of phenazines via Cu-catalyzed homocoupling of 2-iodoanilines or 2-bromoanilines in water has been developed. Asymmetric phenazines could be also successfully synthesized by cross-coupling between two different 2-iodoanilines in moderate yields.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Phenazines could be easily prepared by homocoupling of 2-iodoanilines or 2-bromoanilines. ► The catalyst Sulfonato-Cu(salen) was easily prepared and showed high catalytic abilities. ► Water was used as sole solvent instead of usually used organic media. ► The reactions could be carried out in the air under mild conditions.