| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1323383 | Journal of Organometallic Chemistry | 2015 | 5 Pages |
•Gold-catalyzed cascade cyclization of (azido)ynamides is developed.•[1,4]Oxazino[3,2-b]indoles and 1H-pyrazino[2,3-b]indoles are constructed readily.•The scope of the present cascade reaction is extended.•Good to excellent yields are achieved.•A plausible mechanism to rationalize the catalytic transformation is proposed.
[1,4]Oxazino[3,2-b]indoles as well as 1H-pyrazino[2,3-b]indoles are constructed in good to excellent yields via gold-catalyzed cascade cyclization of (azido)ynamides. The use of readily available starting materials, a simple procedure and mild reaction conditions are other significant features of this method.
Graphical abstract[1,4]Oxazino[3,2-b]indoles as well as 1H-pyrazino[2,3-b]indoles are constructed in good to excellent yields via gold-catalyzed cascade cyclization of (azido)ynamides. The use of readily available starting materials, a simple procedure and mild reaction conditions are other significant features of this method.Figure optionsDownload full-size imageDownload as PowerPoint slide
![Facile and efficient synthesis of [1,4]oxazino[3,2-b]indoles and 1H-pyrazino[2,3-b]indoles through gold-catalyzed cascade cyclization of (azido)ynamides](/preview/png/1323383.png "First Page Preview: Facile and efficient synthesis of [1,4]oxazino[3,2-b]indoles and 1H-pyrazino[2,3-b]indoles through gold-catalyzed cascade cyclization of (azido)ynamides")