A recyclable palladium-catalyzed modified Friedländer quinoline synthesis

2-Aminobenzyl alcohol reacts with an array of ketones in toluene/poly(ethylene glycol) (PEG-2000) at 100 °C in the presence of a palladium catalyst along with KOH under an atmosphere of air to give the corresponding quinolines in good yields. The catalytic system could be recovered and reused five times without any loss of catalytic activity.

Graphical abstract2-Aminobenzyl alcohol undergoes oxidative cyclization with an array of ketones in toluene/poly(ethylene glycol) (PEG-2000) at 100 °C in the presence of a catalytic amount of Pd(OAc)2 together with KOH to afford quinolines. The solidified palladium catalyst/PEG-2000 could be recovered and reused five times without any loss of catalytic activity.Figure optionsDownload full-size imageDownload as PowerPoint slide