Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1323444 | Journal of Organometallic Chemistry | 2015 | 6 Pages |
•Six new dinuclear arene ruthenium complexes with different arenes have been prepared.•All complexes are soluble and stable in H2O at 37 °C and less soluble in a 100 mM aqueous NaCl solution.•Two complexes show high in vitro anticancer activity with IC50 values inferior to 0.06 μM for the A2780 cell line.•The cytotoxicity is in line with the lipophilicity of the arene.•Arene ligand is an important parameter that should be more systematically evaluated.
A new series of cationic dinuclear arene ruthenium complexes bridged by three thiophenolato ligands, [(η6-arene)2Ru2(μ2-SR)3]+ with arene = indane, R = met: 1 (met = 4-methylphenyl); R = mco: 4 (mco = 4-methylcoumarin-7-yl); arene = biphenyl, R = met: 2; R = mco: 5; arene = 1,2,3,4-tetrahydronaphthalene, R = met: 3; R = mco: 6, have been prepared from the reaction of the neutral precursor [(η6-arene)Ru(μ2-Cl)Cl]2 and the corresponding thiophenol RSH. All cationic complexes have been isolated as chloride salts and fully characterized by spectroscopic and analytical methods. The molecular structure of 1, solved by X-ray structure analysis of a single crystal of the chloride salt, shows the two ruthenium atoms adopting a pseudo-octahedral geometry without metal–metal bond in accordance with the noble gas rule. All complexes are stable in H2O at 37 °C, but only 1 remains soluble in a 100 mM aqueous NaCl solution, while significant percentages (30–60 %) of 2–6 precipitate as chloride salts under these conditions. The 4-methylphenylthiolato complexes (R = met) are highly cytotoxic towards human ovarian cancer cells, the IC50 values being in the sub-micromolar range, while the 4-methylcoumarin-7-yl thiolato complexes (R = mco) are only slightly cytotoxic. Complexes 1 and 3 show the highest in vitro anticancer activity with IC50 values inferior to 0.06 μM for the A2780 cell line. The results demonstrate that the arene ligand is an important parameter that should be more systematically evaluated when designing new half-sandwich organometallic complexes.
Graphical abstractCationic dinuclear arene ruthenium complexes [(η6-arene)2Ru2(μ2-SR)3]+ with arene = indane, biphenyl, 1,2,3,4-tetrahydronaphtalene, (1 - 6) have been prepared. Two complexes show in vitro anticancer activity with IC50 values inferior to 0.06 μM for the A2780 cell line.Figure optionsDownload full-size imageDownload as PowerPoint slide