Ruthenium catalyzed oxidative annulation with alkynes via cascade C–H/N–H bond functionalizations

•Domino C–H/N–H bond functionalizations.•Ruthenium complexes.•Oxidative annulation reaction.•Efficient access to isoquinolines.•Open-flask condition.

Ruthenium(II) complexes catalyzed tandem C–H/N–H bonds functionalizations of 2-phenyl imidazole and its derivatives with alkynes were realized. This transformations allowed for rapid synthesis of isoquinoline derivatives under open-flask condition.

Graphical abstractRuthenium catalyzed oxidative annulation with alkyne via cascade C–H/N–H bond functionalization, which efficiently provided structure-complex isoquinolines.Figure optionsDownload full-size imageDownload as PowerPoint slide