Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1323717 | Journal of Organometallic Chemistry | 2011 | 5 Pages |
Highly functionalized tetrasubstituted allylic alcohols were prepared conveniently by CuI-catalyzed tandem carbomagnesiation/carbonyl addition of Grignard reagents with acetylenic ketones. The obtained allylic alcohols can be further transformed to polysubstituted indenes by intramolecular cyclization.
Graphical abstractHighly functionalized tetrasubstituted allylic alcohols were prepared conveniently by CuI-catalyzed tandem carbomagnesiation/carbonyl addition of Grignard reagents with acetylenic ketones. The obtained allylic alcohols can be further transformed to polysubstituted indenes by intramolecular cyclization.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► One-pot tandem reaction of Grignard reagents and acetylenic ketones was studied. ► Highly functionalized tetrasubstituted allylic alcohols were synthesized. ► The obtained allylic alcohols can be further transformed to polysubstituted indenes.