Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1323768 | Journal of Organometallic Chemistry | 2006 | 10 Pages |
Abstract
Total Synthesis of (±)-erythrocarine was achieved using ruthenium-catalyzed dienyne metathesis as a key step. A tetrahydroisoquinoline skeleton having tetrasubstituted carbon center was constructed using our method, that is, carbon dioxide and an alkyl group were introduced onto an alkyne having a heteroatom in a tether using the nickel complex to produce α,β-unsaturated carboxylic acid and then isoquinoline skeleton was constructed by Michael reaction of the tethered nitrogen to the resultant α,β-unsaturated ester.
Graphical abstractTotal Synthesis of (±)-erythrocarine was achieved using ruthenium-catalyzed dienyne metathesis as a key step.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Kazuya Shimizu, Masanori Takimoto, Yoshihiro Sato, Miwako Mori,