A new, modular approach towards 2-(1-hydroxyalkyl)oxazolines, effective bidentate chiral ligands

Addition of β-hydroxyisonitriles towards aldehydes gives rise to hydroxyalkyl oxazolines, an interesting class of bidentate chiral ligands. This concept allows a very easy ligand tuning and optimization of the ligand structure as illustrated in a first example.

Graphical abstractAddition of β-hydroxyisonitriles towards aldehydes gives rise to hydroxyalkyl oxazolines, an interesting class of bidentate chiral ligands. This concept allows a very easy ligand tuning and optimization of the ligand structure as illustrated in a first example.Figure optionsDownload full-size imageDownload as PowerPoint slide