New dimeric and supramolecular organotin(IV) complexes with a tridentate schiff base as potential biocidal agents

The paper describes the synthesis and structural characterization of six new diorganotin(IV) compounds 1–6, [R2SnL] and a monoorganotin(IV) derivative, C4H9SnClL (7). Here L = N′-(5-bromo-2-oxidobenzylidene)-N-(oxidomethylene)hydrazine ligand with ONO tridentate chelation capability and R = CH3 (1), C2H5 (2), n-C4H9 (3), C6H5 (4), C8H17 (5), tert-C4H9 (6), The packing diagram offers a supramolecular structure for 1 and a dimeric structure for 4 with distorted square-pyramidal and distorted trigonal geometry, respectively. The different geometry of 1 than 4 can be attributed to the presence of intermolecular non-covalent Sn---O and Sn---H interactions in the former. The antifungal, antibacterial, antiurease and antileishmanial activities of these complexes proved them to be active biologically and may be formulated as new metal-based drugs in future.

Graphical abstractThe paper describes the synthesis and structural characterization of seven new diorganotin(IV) compounds. The X-ray analysis revealed that the intermolecular non-covalent Sn---O and Sn---H interactions is responsible for variation in structure motifs. The antifungal, antibacterial, antiurease and antileishmanial activities of these complexes proved them to be active biologically and may be formulated as new metal-based drugs in future.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► New organotin(IV) derivatives of a ONO tridentate schiff base were prepared in good yield. ► Intermolecular Sn---O and Sn---H interactions are responsible for structural diversity. ► They have good antifungal, antibacterial, antiurease and antileishmanial activities.