Highly regioselective ruthenium-catalyzed direct arylation of thiazolo[3,2-b]-1,2,4-triazoles with aryl iodides and aryl bromides via C–H bond activation

•Ru-catalyzed arylation of thiazolo[3,2-b]-1,2,4-triazoles with aryl halides formed C–C bond.•Develop an efficient method for the synthesis of polysubstituted thiazolo[3,2-b]-1,2,4-triazoles.•Substituted aryl iodides had given in good yields.

We have developed a convenient ruthenium-catalyzed direct arylation for highly regioselective synthesis of thiazolo[3,2-b]-1,2,4-triazole derivatives via C–H bond activation. This transformation has provided a new synthetic route to a variety of thiazolo[3,2-b]-1,2,4-triazoles and afforded desired products in good yields.

Graphical abstractRegioselective and direct Ru3(CO)12-catalyzed arylation of thiazolo[3,2-b]-1,2,4-triazoles with aryl iodides and aryl bromides via C–H bond activation.Figure optionsDownload full-size imageDownload as PowerPoint slide