Hydrogenation of β-N-substituted enaminoesters in the presence of ruthenium catalysts

β-Aminoesters were prepared in two simple steps from β-ketoesters derivatives and primary amines under mild conditions. Their hydrogenation was performed at 50 °C in the presence of several organometallic catalysts under acidic conditions. The new β-N-substituted aminoesters were isolated in moderate to good yields.

Graphical abstractA new general procedure have been developed for the synthesis of a range of β-N-substituted aminoesters via catalytic hydrogenation of β-N-substituted enaminoesters in acidic conditions in the presence of ruthenium complexes.Figure optionsDownload full-size imageDownload as PowerPoint slide