| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1324725 | Journal of Organometallic Chemistry | 2012 | 8 Pages |
Staring from l-lactide and ε-caprolactone, the corresponding lactic-caprolactone cooligomer with hydroxyl and carboxylic acid groups were synthesized. These oligomers were connected with chelating groups through a long chain tether, ready for transition metal binding. Coordination of organometallic rhenium(I) and technetium(I) complexes generated the conjugates in high yield and short time, satisfying the requirements for short-lived radiopharmaceuticals in clinical applications. A reasonable pharmacophore model has been established to guide the design of well-defined lactic acid oligomer for nuclear medicine.
Graphical abstractWe prepared molecularly defined LA-CL oligomers with terminal functional groups. These oligomers were connected with chelating groups through a long chain tether. Coordination of organometallic rhenium(I) and technetium(I) complexes generated the conjugates in high yield and short time, satisfying the requirements for radiopharmaceuticals in clinical applications.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Molecularly defined LA-CL cooligomer with –OH or –COOH groups were synthesized. ► The LA-tridentate-Re(I) complexes were synthesized and fully characterized. ► 99mTc(I) labeled LA conjugates was synthesized in a short time, and a high yield. ► The 99mTc(I)-LA maintain excellent in vitro stability in PBS.
