| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1324762 | Journal of Organometallic Chemistry | 2011 | 7 Pages |
Four diorganotin(IV) complexes [(Me)2Sn(L1)(CH3COO)]·CH3CH2OH (1), [(Ph)2Sn(L1)(CH3COO)]·CH3CH2OH (2), [(Me)2Sn(L2)Cl] (3) and [(Ph)2Sn(L2)(CH3COO)] (4) where HL1 = 2-benzoylpyridine N(4)-phenylthiosemicarbazone and HL2 = 2-acetylpyrazine N(4)-phenylthiosemicarbazone have been synthesized and characterized by elemental analysis, IR MS, 1H NMR and single-crystal X-ray diffraction studies. Schiff bases in their deprotonated forms coordinate to tin(IV) via pyridine/pyrazine nitrogen atom and the nitrogen atom and sulfur atoms of the thiosemicarbazone moiety. The tin atom is seven-coordinated in 1, 2 and 4 containing one acetato group, respectively, and six-coordinated in 3 containing one chloride ion. Biological studies, carried out in vitro against selected bacteria and K562 leukaemia cells, respectively, have shown that different substituted groups attached at the thiosemicarbazone moieties and different diorganotin(IV) groups showed distinctive differences in the biological property.
Graphical abstractFour diorganotin(IV) complexes [(Me)2Sn(L1)(CH3COO)]·CH3CH2OH (1), [(Ph)2Sn(L1)(CH3COO)]·CH3CH2OH (2), [(Me)2Sn(L2)Cl] (3) and [(Ph)2Sn(L2)(CH3COO)] (4) where HL1 = 2-benzoylpyridine N(4)-phenylthiosemicarbazone, HL2 = 2-acetylpyrazine N(4)-phenylthiosemicarbazone have been synthesized and characterized by elemental analysis, IR MS, 1H NMR and single-crystal X-ray diffraction studies. Schiff bases in their deprotonated forms coordinate to tin(IV) via pyridine/pyrazine nitrogen atom and the nitrogen atom and sulfur atoms of the thiosemicarbazone moiety. The tin atom is seven-coordinated in 1, 2 and 4 containing one acetato group, respectively, and six-coordinated in 3 containing one chloride ion. Biological studies, carried out in vitro against selected bacteria and K562 leukaemia cells, respectively, have shown that different substituted groups attached at the thiosemicarbazone moieties and different diorganotin(IV) groups showed distinctive differences in the biological property.Figure optionsDownload full-size imageDownload as PowerPoint slideResearch highlights► Four diorganotin(IV) complexes have been synthesized and fully characterized. ► The tin atoms showed different coordination modes and formation of 7-coordinated structure is interesting. ► Different substitutents of tin and ligands showed distinctive differences in the biological property. ► The complexes studied would be good candidates to be used for medical practice as metal-based drugs.
