Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1324884 | Journal of Organometallic Chemistry | 2011 | 8 Pages |
Asymmetric intramolecular hydroamination reaction is a stately way to prepare chiral nitrogen-containing heterocyclic compounds. We report in this account our personal contribution in this field with the synthesis of chiral amido rare-earth complexes. A new family of structurally defined heterobimetallic rare earth lithium ate complexes based on N-substituted binaphthylamido ligands was discovered that promoted the hydroamination/cyclization of aminoolefins with up to 87% ee.Neutral rare earth amido and amido alkyl complexes could also be prepared and led to very active species. A more simple and reliable synthetic procedure was discovered towards the preparation of heterobimetallic rare earth amido alkyl ate complexes. They proved to be also active and enantioselective catalysts, as a good compromise between efficiency and practicability issues.
Graphical abstractShort account of recent personal research: new families of chiral binaphthylamido-based rare-earth complexes are efficient catalysts to promote the enantioselective intramolecular hydroamination of various aminoalkene derivatives.Figure optionsDownload full-size imageDownload as PowerPoint slide