Article ID Journal Published Year Pages File Type
1325040 Journal of Organometallic Chemistry 2007 6 Pages PDF
Abstract

Aminoferrocene, H2N–Fc, has been substituted to the C-terminus of six amino acids using the HBTU/HOBt coupling protocol. The synthesized bioconjugates Boc-Aaa-NH-Fc, Aaa = Gly (1), Leu (2), Phe (3), Val (4), Cys(Acm) (5), Tyr(tBu) (6) (Acm = acetamidomethyl, tBu = tert-butyl), have been characterized by 1H NMR, 13C NMR, EI-MS, EI-HRMS, UV and CD spectroscopies. In addition, a VT NMR study on 4 and the X-ray structure of 1 are presented.

Graphical abstractThe first amino acid derivatives of aminoferrocene are reported. Six derivatives with different R groups, derived from naturally occurring amino acids were prepared. The glycine derivative has been structurally characterized and hydrogen bonding interactions were investigated by CD and NMR spectroscopy.Figure optionsDownload full-size imageDownload as PowerPoint slide

Related Topics
Physical Sciences and Engineering Chemistry Inorganic Chemistry
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