Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1325142 | Journal of Organometallic Chemistry | 2009 | 6 Pages |
Nine amide-functionalized titanocenyls have been synthesized and characterized by spectroscopic and analytical methods and the solid state structure of Cp(CpCO-NH-C6H4-OCF3)TiCl2 was determined by single crystal X-ray diffraction. X-ray analysis of Cp(CpCO-NH-C6H4-OCF3)TiCl2 showed that titanium is in a pseudo tetrahedral geometry and contains a Ti–O(amide) coordination. In principle, Ti–O coordination should provide more hydrolytic stability to the corresponding titanocenyls than titanocene dichloride. The cytotoxic activities of these amide-functionalized titanocenyls on HT-29 colon cancer cell line were determined by MTT assay to elucidate structure-activity relationship. All complexes were more cytotoxic than titanocene dichloride and there is no correlation between the para substituents on the phenyl ring and their cytotoxicities.
Graphical abstractNine amide-functionalized titanocenyls have been synthesized, characterized and their cytotoxic properties on colon cancer cell line HT-29 investigated. All titanocenyl complexes were more cytotoxic than titanocene dichloride and there is no correlation between the para substituents on the phenyl ring and their cytotoxicities.Figure optionsDownload full-size imageDownload as PowerPoint slide