N-acylbenzotriazole mediated microwave assisted synthesis of protected and novel unprotected ferrocenoylamidoamino acids

In this study, crystalline and chirally stable carboxyl-protected and novel unprotected N-ferrocenoyl amino acid derivatives of Ser, Cys, Ala, Phe, Trp, Asp and Asn have been prepared. These amino acids undergo substitution reaction with 1-(ferrocenylcarbonyl)-1H-benzotriazole, 1, in partially aqueous media under microwave irradiation.

Graphical abstractN-Ferrocenoylbenzotriazole mediated preparation of carboxy-protected and unprotected ferrocenoylamidoamino acids were prepared under microwave irradiation.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Crystalline, chirally stable carboxy-protected and novel unprotected N-ferrocenoyl amino acid derivatives were prepared. ► During preparation of target molecules, 1-(ferrocenylcarbonyl)-1H-benzotriazole was used as a starting material under MW irradiation. ► Prepared unprotected N-ferrocenoylamidoamino acid can be used for peptide coupling with different amino acids, without any protection and deprotection process.