Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1325571 | Journal of Organometallic Chemistry | 2014 | 7 Pages |
•Aryl iodides are required for a successful outcome of the reaction.•This Pd-catalysed domino sequence involves a C–C and an N–C bond formation.•The protection of the amino group was necessary for the Pd-catalysed domino reaction.
Vinyl-substituted 1,4-benzodiazepinones were obtained in good yields (10 examples, 61–82% yield) via the reaction between N-allenyl anthranyl amides and aryl iodides under Pd(0) catalysis. This new single cycle catalytic domino transformation involves a C–C followed by an N–C bond formation.
Graphical abstractN-Allenyl anthranyl amides and aryl iodides react to give vinyl-substituted benzodiazepinones. This new Pd-catalysed domino sequence involves a C–C followed by an N–C bond formation.Figure optionsDownload full-size imageDownload as PowerPoint slide