| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1325582 | Journal of Organometallic Chemistry | 2014 | 8 Pages |
•Ten new ruthenium(II) complexes with carbohydrate derivative ligands were synthesized.•The cytotoxicity of the complexes was tested on HeLa cancer cells (cervical carcinoma).•The IC50 values are lower than cisplatin, in the low micromolar range.
We here report the synthesis of new cyclopentadienyl ruthenium(II) complexes of general formula [(η5-C5H5)Ru(PP)(L)]+ (PP = two triphenylphosphine, 1,2-diphenylphosphinoethane), isolated as PF6− salts, with L being galactose and fructose carbohydrate derivative ligands, N-coordinated to the metal centre by nitrile, tetrazole and 1,3,4-oxadiazole moieties. The ten new organometallic compounds were fully characterized by FT-IR, 1H, 13C, and 31P NMR spectroscopies, and by elemental analysis. The cytotoxicity of the ruthenium(II) compounds was tested on HeLa cancer cells (cervical carcinoma), unveiling IC50 values in the low micromolar range.
Graphical abstractThe synthesis, characterization and cytotoxic evaluation of new cyclopentadienylruthenium(II) complexes of general formula [(η5-C5H5)Ru(PP)L][PF6], (PP = two triphenylphosphine, 1,2-diphenylphosphinoethane), L being galactose and fructose carbohydrate derivative ligands, N-coordinated to the metal centre by nitrile, tetrazole and 1,3,4-oxadiazole moieties, is described.Figure optionsDownload full-size imageDownload as PowerPoint slide
