New tetrahedral, square-pyramidal, trigonal-bipyramidal and octahedral organotin(IV) 4-ethoxycarbonylpiperazine-1-carbodithioates: Synthesis, structural properties and biological applications

This article describes the synthesis of triorganotin(IV)-, chlorodiorganotin(IV)- and diorganotin(IV) 4-ethoxycarbonylpiperazine-1-carbodithioates with general R3SnL {where R = CH3 (1), n-C4H9 (2) and C6H5 (3)}, R2SnClL {where R = CH3 (4), n-C4H9 (5) and C6H5 (6)} and R2SnL2 {where R = CH3 (7), n-C4H9 (8) and C6H5 (9)}, respectively. The coordination behavior of ligand (L) in all compounds was investigated by different analytical techniques such as FT-IR and multinuclear NMR. X-ray single crystal analysis confirmed supramolecular structure for compounds (3) and (4) with distorted trigonal-bipyramidal and distorted square-pyramidal geometries, respectively. The compounds have pronounced antimicrobial (antibacterial and antifungal) potency and moderate insecticidal activity. These compounds also inhibit effectively the activity of urease enzyme.

Graphical abstractA series of new supramolecular triorganotin(IV)-, chlorodiorganotin(IV)- and diorganotin(IV) 4-ethoxycarbonylpiperazine-1-carbodithioates have been synthesized and fully characterized. The pronounced bioactivity of these compounds is presumably due to the formation of secondary interactions with cell constituents.Figure optionsDownload full-size imageDownload as PowerPoint slide