| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1326097 | Journal of Organometallic Chemistry | 2005 | 9 Pages |
The activity of well-defined N-heterocyclic carbene (NHC)-palladium acetate complexes has been studied in the α-arylation of ketones. The enolate was generated in situ via use of slight excess of sodium tert-butoxide as base. The results showed a high activity, allowing for the coupling of non-activated chlorides. The use of hindered substrates provided an avenue for convenient synthesis of various ketone derivatives. The first examples of α-arylation of ketones at room temperature mediated by an NHC-ligated catalyst are also presented.
Graphical abstractThe activity of well-defined N-heterocyclic carbene (NHC)-palladium acetate complexes has been studied in the α-arylation of ketones. Catalytic results indicate a high activity. The use of hindered substrates provide an avenue for convenient synthesis of various ketone derivatives. The first examples of α-arylation of ketones at room temperature mediated by an NHC-bearing catalyst are also presented.Figure optionsDownload full-size imageDownload as PowerPoint slide
