Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1326134 | Journal of Organometallic Chemistry | 2005 | 5 Pages |
Simple palladium-N-heterocyclic carbene catalysts readily effect the palladium-catalyzed cyclization-trapping of bisdienes with sulfonamides. The reaction is quite efficient for a variety of sulfonamides and several bisdienes. For example, using 0.1% of the in situ generated or preformed (IMes)Pd(η3-C3H5)Cl complex, the cyclization-trapping of a simple bisdiene with TsN(H)CH2Ph proceeds in good yield under thermal conditions (74–75%, 75 °C, 9 h). The same reaction run under microwave irradiation proceeds somewhat faster and in even higher yield (86%, 75 °C, 2.5 h).
Graphical abstractSimple (NHC)Pd catalysts effect the efficient cyclization-trapping of bisdienes with sulfonamides. For example, the (IMes)Pd-catalyzed (0.1%, generated in situ) cyclization-trapping of a simple bisdiene with TsN(H)CH2Ph proceeds in 86% yield upon microwave heating at 75 °C (<250 W, 2.5 h).Figure optionsDownload full-size imageDownload as PowerPoint slide