Synthesis, crystal structure and biological activities of two novel organotin(IV) complexes constructed from 12-(4-methylbenzoyl)-9,10-dihydro-9,l0-ethanoanthracene-11-carboxylic acid

Two complexes: [(n-Bu2Sn)4(L)2O2(OC2H5)2] (1) and [(C6H5)3Sn(L)] (2) (where, HL is 12-(4-methylbenzoyl)-9,10-dihydro-9,10-ethanoanthracene-11-carboxylic acid) have been prepared and structurally characterized by means of elemental analysis and vibrational, 1H NMR and FT-IR spectroscopies. The crystal structures of 1 and 2 have been determined by X-ray crystallography. Three distannoxane rings are present to the centrosymmetric dimeric tetraorganodistannoxane by virtue of μ3-oxo form the central R4Sn2O2 core with a planar Sn2O2 ring, resulting in a ladder type structural motif in the molecular structure of 1, and five-coordinated tin atoms are present in the distannoxane dimer. While the molecular of 2 adopts a monomeric distorted tetrahedral configuration with the carboxylate ligand coordinating in a monodentate mode. Both 1 and 2 exhibited good antibacterial and antitumour activities and have a potential to be used as drugs.

Graphical abstractTwo complexes 1 and 2 have been synthesized by the reaction of 12-(4-methylbenzoyl)-9,10-dihydro-9,10-ethanoanthracene-11-carboxylic acid with n-Bu2SnO and (C6H5)3SnOH by azeotropic dehydration in the solvent of absolute benzene, respectively. The crystal structures of both two complexes have been determined by X-ray crystallography.Figure optionsDownload full-size imageDownload as PowerPoint slide