Influence of structural changes in ferrocene phosphane aminophosphane ligands on their catalytic activity

New phosphane aminophosphane ligands based on [3]ferrocenophane skeleton were synthesized using a direct double lithiation followed by phosphanylation. Influence of ligand structure on catalytic performance was evaluated by performing a series of Pd-catalyzed allylic substitution on different substrates. Enantioselectivities up to 55% ee were obtained with bridged ligand compared to 33% ee with analogous non-bridged BoPhoz ligand.

Graphical abstractNew [3]ferrocenophane analog of BoPhoz ligand can be efficiently prepared by one-pot double lithiation followed by phosphanylation. Its catalytic properties are evaluated in Pd-catalyzed allylic substitution.Figure optionsDownload full-size imageDownload as PowerPoint slide