The particular role of radiopharmacy within bioorganometallic chemistry

This article will emphasize the particular role of organometallic radiopharmaceutical chemistry, namely the need for syntheses from water and the emerging implications for other (bio)organometallic fields. After some basic insights into the different directions of bioorganometallic chemistry, some facets of the [M(CO)3]+ (M = Tc, Re) moiety are reviewed and discussed in the respective context. The mechanism for the synthesis of [M(OH2)3(CO)3]+ which is still little understood, will be touched. The formation of additional M–C bonds is exemplified with cyclopentadienyl chemistry, the potential impact on targeted molecular imaging with the labelling of amino acids and the reactivity towards essential biomolecules such as guanine is shown. Future perspectives and implications for organometallic radiopharmaceutical chemistry will close this article.

Graphical abstractBasic insights into the different directions of bioorganometallic chemistry and some facets of the [M(CO)3]+ (M = Tc, Re) moiety are reviewed in general. Specifically, the synthesis of [M(OH2)3(CO)3]+ and its impact on radiopharmaceutical chemistry is described. The formation of additional M–C bonds in water is exemplified with cyclopentadienyl chemistry, the perspectives on targeted molecular imaging with the labelling of amino acids and the reactivity towards essential biomolecules such as guanine is shown.Figure optionsDownload full-size imageDownload as PowerPoint slide