Article ID Journal Published Year Pages File Type
1326849 Journal of Organometallic Chemistry 2007 5 Pages PDF
Abstract

A series of N-(ferrocenylmethyl)benzene-carboxamide derivatives (4a–f) have been synthesised by coupling ferrocenylmethyl amine 3 with benzoic acid and various substituted fluorobenzoic acids using the standard 1,3-dicyclohexylcarbodiimide (DCC), 1-hydroxybenzotriazole (HOBt) protocol. All compounds were fully characterised using a combination of 1H NMR, 13C NMR, 19F NMR, DEPT-135, 1H–1H COSY and 1H–13C COSY (HMQC) spectroscopy and electrospray ionisation mass spectrometry (ESI-MS). The compounds 4a, 4d, 4e and 4f exhibited cytotoxic effects on the MDA-MB-435-S-F breast cancer cell line. Single crystal X-ray crystallographic data for 4d is also presented.

Graphical abstractA series of N-(ferrocenylmethyl)benzene-carboxamide derivatives (4a–f) have been synthesised by coupling ferrocenylmethyl amine 3 with benzoic acid and various substituted fluorobenzoic acids using the standard 1,3-dicyclohexylcarbodiimide (DCC), 1-hydroxybenzotriazole (HOBt) protocol. All the compounds were fully characterised using a combination of 1H NMR, 13C NMR, 19F NMR, DEPT-135, 1H–1H COSY and 1H–13C COSY (HMQC) spectroscopy and electrospray ionisation mass spectrometry (ESI-MS). The compounds 4a, 4d, 4e and 4f exhibited cytotoxic effects on the MDA-MB-435-S-F breast cancer cell line. Single crystal X-ray crystallographic data for 4d is also presented.Figure optionsDownload full-size imageDownload as PowerPoint slide

Related Topics
Physical Sciences and Engineering Chemistry Inorganic Chemistry
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