2-Aminophenyl diphenylphosphinite as an easily accessible ligand for heterogeneous palladium-catalyzed Suzuki–Miyaura reaction in water in the absence of any organic co-solvent

In this article, we have introduced application of 2-aminophenyl diphenylphosphinite as an easily accessible ligand for heterogeneous palladium-catalyzed Suzuki–Miyaura reaction in water in the absence of any organic co-solvent. By using 2-aminophenyl diphenylphosphinite as a ligand and Pd(OAc)2 as the pre-catalyst, structurally different aryl halides (I, Br, Cl) were reacted efficiently with phenylboronic acid in water to produce their corresponding biphenyl products in good to excellent yields under heterogeneous conditions. The catalyst is recyclable and was recycled for seven runs for the reaction of bromobenzene with phenylboronic acid without appreciable loss of its catalytic activity.

Graphical abstractIn this article we have introduced another useful application of 2-aminophenyl diphenylphosphinite as an easily prepared and cheap ligand for heterogeneous palladium-catalyzed Suzuki–Miyaura reaction in water in the absence of any organic co-solvent. By using 2-aminophenyl diphenylphosphinite ligand and Pd(OAc)2 as the pre-catalyst in water, structurally different aryl halides (I, Br, Cl) were efficiently converted to their biphenyl products in good to excellent yields by the reaction with phenyboronic acid under heterogeneous conditions. The heterogeneous catalyst was recyclable and was recycled for several runs for the reaction of bromobenzene with phenylboronic acid.Figure optionsDownload full-size imageDownload as PowerPoint slide