On the reaction of 4-substituted trimethyltin aromatics with perchlorylfluoride

To evaluate the suitability of [18F]perchorylfluoride [18F]FClO3 as an electrophilic fluorination agent for the preparation of radiopharmaceuticals, the reactivity non-radioactive FClO3 towards 4-substituted trimethyltin aromatic compounds was studied. Contrary to the expectation, an electrophilic fluorination of the aromatic nucleus did not occur. The reaction of perchlorylfluoride with aromatic trimethylstannyl compounds resulted in the formation of trimethyltin fluoride and the respective destannylated aromatics in variable yields.

Graphical abstractThe reactivity of 4-substituted trimethyltin aromatic compounds towards FClO3 was studied.Figure optionsDownload full-size imageDownload as PowerPoint slide