A catalyst-free synthesis of asymmetric diaryl ketones from aryltins

A series of diaryl ketones have been synthesized in good yields (40–78%) through the catalyst-free reaction of trimethylarylstannanes with aroyl chlorides in chlorobenzene as solvent. In addition, an attractive feature is that these reactions are completely regioselective making possible the synthesis of diarylketones which are not usually available under the influence of the directing forces of the substituents present in the aromatic ring. Also, the reaction conditions are mild enough to be applied to acid sensitive molecules.

Graphical abstractA series of diaryl ketones have been synthesized in good yields (40–78%) through the catalyst-free reaction of trimethylarylstannanes with aroyl chlorides. In addition, an attractive feature is that these reactions are completely regioselective making possible the synthesis of diarylketones which are not usually available under the influence of the directing forces of the substituents present in the aromatic ring.Figure optionsDownload full-size imageDownload as PowerPoint slide