| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1327170 | Journal of Organometallic Chemistry | 2006 | 10 Pages |
The complex [(C6H5)2SnCl(HMNA)] (1) where H2MNA is thioamide 2-mercapto-nicotinic acid has been synthesized by reacting a methanolic solution of di-chloro-di-phenyltin(IV) Ph2SnCl2 with an aqueous solution of 2-mercapto-nicotinic acid, containing twofold amount of potassium hydroxide. The Sn/ligand molar ratio is 2:1. The complex was characterized by elemental analysis, FT-IR and Mössbauer spectroscopic techniques. In addition the crystal structure of the molecule was determined by an X-ray diffraction at 293(2) K. C18H14ClNO2SSn is monoclinic, space group P21/n, a = 15.089(3) Å, b = 15.846(3) Å, c = 16.691(3) Å, β = 105.57(3)°, Z = 8. The ligand coordinates to the metal center through the exocyclic sulfur and the heterocyclic nitrogen atoms, forming a four membered ring. The coordination sphere around the tin(IV) ion is completed with two carbon atoms from the two phenyl groups and one chlorine atom. The geometry around the tin atom can be described either as trigonal bipyramidal or tetragonal pyramidal. Finally, the influence of the complex [(C6H5)2SnCl(HMNA)] (1) upon the catalytic peroxidation of linoleic acid to hydroperoxylinoleic acid by the enzyme lipoxygenase (LOX) was also kinetically and theoretically studied and the results compared with the ones of the corresponding binuclear complex [(C6H5)3Sn(MNA)Sn(C6H5)3 · (acetone)] (2) reported in the literature.
Graphical abstractThe complex [(C6H5)2SnCl(HMNA)] (1) (H2MNA = 2-mercapto-nicotinic acid) has been synthesized and characterized by e.a., FT-IR and Mössbauer spectroscopic techniques and X-ray crystallography. The influence of the complex [(C6H5)2SnCl(HMNA)] (1) upon the catalytic peroxidation of linoleic acid to hydroperoxylinoleic acid by the enzyme lipoxygenase (LOX) was also kinetically and theoretically studied.Figure optionsDownload full-size imageDownload as PowerPoint slide
