Addition of heterocycles to electron deficient olefins and alkynes catalyzed by gold(III)

A gold(III)-catalyzed hydroarylation of different olefins is reported here. AuCl3 works as an excellent catalyst to mediate reactions between various heterocycles and electron deficient olefins and alkynes under mild conditions. This gold(III)-based method tolerates different functional groups such as aldehyde, carboxylic acid, nitrile, and is highly efficient. We have shown that some of these reactions complete in minutes at room temperature.

Graphical abstractAuCl3 works as an excellent catalyst to mediate C–C bond formation between various heterocycles and electron deficient olefins and alkynes under mild conditions. Functional groups such as aldehyde, carboxylic acid and nitrile can be tolerated in these reactions.Figure optionsDownload full-size imageDownload as PowerPoint slide