Application of dimeric orthopalladate complex of homoveratrylamine as an efficient catalyst in the Heck cross-coupling reaction

The [Pd{C6H2(CH2CH2NH2)-(OMe)2,3,4} (μ-Br)]2 complex of homoveratrylamine was synthesized and its application in the Heck coupling reaction was studied. This complex had been demonstrated to be active and efficient catalyst for the Heck reaction of aryl iodides, bromides and even chlorides. The cross-coupled products were produced in excellent yields in a short reaction time using catalytic amounts of [Pd{C6H2(CH2CH2NH2)-(OMe)2,3,4} (μ-Br)]2 complex in N-methyl-2-pyrrolidinone (NMP at 130 °C).

Graphical abstractThe [Pd{C6H2(CH2CH2NH2)-(OMe)2,3,4} (μ-Br)]2 complex of homoveratrylamine was synthesized and its application in Heck coupling reaction was studied. This complex had been demonstrated to be active and efficient catalyst for the Heck reaction of aryl iodides, bromides and even chlorides. The cross-coupled products were produced in excellent yields in short reaction time using catalytic amount of [Pd{C6H2(CH2CH2NH2)-(OMe)2,3,4} (μ-Br)]2 complex in NMP at 130 °C.Figure optionsDownload full-size imageDownload as PowerPoint slide