A new signal processing method to observe weak 31P and 17O NMR peaks

In NMR spectroscopy, situations may arise where sample concentrations are below the threshold for FT NMR detection, or sample lability constrains allowable acquisition times. In 31P NMR, for example, observation of 13C satellites may not be practical under given conditions. For 17O NMR, which is useful to characterize 17O-labeled phosphate derivatives, similar considerations may apply, and added factors are the cost of isotopically enriched samples and the requirement to obtain spectra at relatively high temperatures if narrow spectral peak line widths are desired. We report here application of a new signal processing method [S.D. Kunikeev, H.S. Taylor, J. Phys. Chem. A 108, 2004 743] to observation of weak 31P and 17O NMR peaks.

Graphical abstractA new harmonic inversion (HI) signal processing method provided better 31P and 17O NMR peak detection sensitivity than a conventional FFT approach when applied to several model samples.Figure optionsDownload full-size imageDownload as PowerPoint slide