| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1327485 | Journal of Organometallic Chemistry | 2005 | 9 Pages |
Abstract
Bisphosphonates, known for their effectiveness in the treatment of osteoporosis, inhibit bone resorption via mechanisms that involve binding to bone mineral and cellular effects on osteoclasts. The major molecular target of nitrogen-containing bisphosphonates (N-BPs) in osteoclasts is farnesyl diphosphate synthase (FPPS).
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Frank H. Ebetino, Christian N. Rozé, Charles E. McKenna, Bobby L. Barnett, James E. Dunford, R. Graham G. Russell, Glen E. Mieling, Michael J. Rogers,