| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1328472 | Journal of Organometallic Chemistry | 2006 | 8 Pages |
La(III) complex with 1-phenyl-3-methyl-5-hydroxy-4-pyrazolyl phenyl ketone (PMBP)-isonicotinoyl hydrazone (La-complex) was synthesized in the work. The crystal of the La-complex was determined by X-ray diffraction analyses, the crystal of the complex is rhomb, space group R3 with Z = 6, the coordination polyhedron of the complex is a tricapped triprism configuration with the nine-coordinate atoms, and the La-complex molecule looks like a helix structure according to its spacefill picture. Besides, it has been discovered that the La-complex possesses cytotoxic activities, and inhibitory rate for Leukemia cells (L1210) is 87.1%. The interaction of the La-complex with DNA was investigated by absorption spectrum, fluorescence, CD spectrum and viscosity measurements. The DNA-binding constant for the La-complex is (4.30 ± 0.14) × 106 M−1.
Graphical abstractLa(III) complex with 1-phenyl-3-methyl-5-hydroxy-4-pyrazolyl phenyl ketone (PMBP)-isonicotinoyl hydrazone (H2L) is a tricapped triprism configuration with the nine-coordinate atoms, the La-complex molecule looks like a helix structure according to its spacefill picture.Figure optionsDownload full-size imageDownload as PowerPoint slide
