| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1344458 | Tetrahedron: Asymmetry | 2011 | 6 Pages |
Abstract
An enantioselective Michael reaction of carbonyl compounds to nitroolefins has been accomplished using a novel chiral pyrrolidine-pyrazole catalyst. This newly prepared catalyst was found to be very effective in providing good yields as well as good diastereo- and enantio-selectivities. The mechanism of the reaction has also been substantiated by mass spectral studies.
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(S)-tert-Butyl-2-((1H-pyrazol-1-yl)methyl)pyrrolidine-1-carboxylateC13H21N3O2[α]D25=-119 (c 1.1, CHCl3)Source of chirality: l-prolineAbsolute configuration: (S)
(S)-1-(Pyrrolidin-2-ylmethyl)-1H-pyrazoleC8H13N3[α]D25=-98 (c 0.9, CHCl3)Source of chirality: l-prolineAbsolute configuration: (S)
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Srivari Chandrasekhar, Togapur Pavan Kumar, Kothapalli Haribabu, Chada Raji Reddy, Chitumalla Ramesh Kumar,