| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1344714 | Tetrahedron: Asymmetry | 2010 | 4 Pages |
Abstract
The asymmetric hydration of α-benzyl-α-methylmalononitrile was examined by using chiral bifunctional catalysts. Enantiomer discrimination of the prochiral dinitrile in the presence of water was demonstrated with a well-defined bifunctional amido-Ru complex having N-sulfonyldiamine ligands, and providing the corresponding amidato(amine) complexes diastereoselectively. Under the catalytic conditions, the (R)-cyanoamide was successfully obtained without further hydrolysis to carboxylic acids.
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Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Shoko Kamezaki, Satoshi Akiyama, Yoshihito Kayaki, Shigeki Kuwata, Takao Ikariya,