Efficient resolution of 2,2′-dihydroxy-1,1′-binaphthalene-4,4′- and 6,6′-dicarboxylic acid by complexation with cinchonidine and brucine

2,2′-Dihydroxy-1,1′-binaphthalene-4,4′- and 6,6′-dicarboxylic acid were resolved efficiently by complexation with cinchonidine and brucine, respectively. The absolute configurations of these compounds were determined by X-ray crystallographic analyses.

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(R)-2,2′-Dihydroxy-1,1′-binaphthalene-4,4′-dicarboxylic acidsC22H14O6[α]D = +46 (c 0.31, EtOH)Source of chirality: resolutionAbsolute configuration: (R)

(R)-2,2′-Dihydroxy-1,1′-binaphthalene-6,6′-dicarboxylic acidsC22H14O6[α]D = +56 (c 0.67, EtOH)Source of chirality: resolutionAbsolute configuration: (R)